Boston CIDAR Study
Longitudinal Assessment and Monitoring of Clinical Status and Brain Function in Adolescents and Adults

Jean A. Frazier, MD




Jean A. Frazier, M.D., is Director of the Child and Adolescent Neuropsychiatric Research Program and Co-Director of the Center for Child and Adolescent Development at Cambridge Health Alliance (CHA), Massachusetts. She is also Director of Child Psychopharmacology at CHA and is Associate Professor of Psychiatry at Harvard Medical School. She received her Medical Degree from Dartmouth Medical School in Hanover, NH, in 1987. She then completed her internship and residency in psychiatry at Tufts-New England Medical Center, and her child and adolescent psychiatry fellowship at Bradley/Rhode Island Hospitals, Brown University. Before coming to Boston, Dr. Frazier completed a research fellowship in the Child Psychiatry Branch of the National Institute of Mental Health in Bethesda, MD, where she focused on the treatment and neurobiology of childhood-onset schizophrenia. She served as Director of the Child Psychiatry Outpatient Program at McLean Hospital for 6 years prior to joining CHA.

Research Summary

Dr. Frazier is interested in early onset psychotic disorders and autism spectrum disorders and how scientific methodology can be implemented for early identification, intervention and prevention. She is currently involved in neuroimaging research designed to study possible clinical and biological correlates of the psychotic process in youths with schizophrenia or bipolar disorder; this is a collaborative enterprise between CHA and McLean Hospital. In addition, Dr. Frazier is principle investigator at the Cambridge site for several medication trials for youth with bipolar disorder, including a national NICHD-funded lithium study, as well as treatment trials for youth with schizophrenia spectrum disorders and with autism spectrum illnesses. Her research group participates in the Harvard-wide NIMH-funded CIDAR project entitled "Vulnerability to Progression in Schizophrenia". Dr. Frazier is also a member of the Executive Committee of the Boston-area Autism Consortium.

Dr. Frazier has published 62 articles (peer reviewed) and 17 book chapters. In addition, she has won numerous awards including the National Alliance for the Mentally Ill-Annual Exemplary Psychiatrist Award, the Massachusetts Psychiatric Society-Outstanding Psychiatrist Award for Research and the Leadership Award from STEP-UP for KIDS.

Selected Publications

  1. Frazier JA, Hodge S, Breeze J, Giuliano A, Terry J, Kennedy D, Lopez-Larson M, Caviness V, Seidman L, Zablotsky B, Makris N. Diagnostic and Sex Effects on Limbic Volumes in Early-Onset Bipolar Disorder and Schizophrenia. Schizophrenia Bulletin, in press.
  2. Frazier JA, McClellan J, Findling RL, Vitiello B, Anderson R, Zablotsky B, Williams E, McNamara NK, Jackson JA, Ritz L, Hlastala SA, Pierson L, Varley JA, Puglia M, Maloney AE, Ambler D, Hunt-Harrison T, Hamer RM, Noyes N, Lieberman JA, Sikich L. Treatment of early-onset schizophrenia spectrum disorders: demographic and clinical characteristics. Journal of the American Academy of Child and Adolescent Psychiatry, 2007; 46: 979-988.
  3. Illowsky Karp B, Garvey M, Jacobsen LK, Frazier JA, Hamburger SD, Bedwell JS, Rapoport JL. Abnormal neurologic maturation in very early onset schizophrenia. American Journal of Psychiatry 2001; 158:118-22.
  4. Frazier JA, Alaghband-Rad J, Jacobsen L, Lenane MC, Hamburger S, Albus K, Smith A, McKenna K, Rapoport JL. Pubertal development and onset of psychosis in childhood onset schizophrenia. Psychiatry Research 1997; 70:1-7.
  5. Frazier JA, Giedd J, Hamburger SD, Albus K, Kaysen D, Vaituzis C, Rajapakse JC, Lenane MC, McKenna K, Jacobsen L, Gordon CT, Breier A, Rapoport JL. Brain anatomic magnetic resonance imaging in childhood onset schizophrenia. Archives of General Psychiatry 1996; 53:617-24.
  6. Kumra S, Frazier JA, Jacobsen LK, McKenna K, Gordon CT, Hamburger S, Smith AK, Albus KE, Alaghband-Rad J, Lenane M, Rapoport JL. Childhood-onset schizophrenia: a double blind clozapine trial. Archives of General Psychiatry 1996; 53:1090-7.
Last updated December 8, 2008.