Michal Pravenec, Ph.D.
![headShot](images/photos/mpravenec.jpg)
Contact
pravenec @ biomed.cas.czWebsite
http://sun2.biomed.cas.cz/fgu/enBiography
Born: August 10, 1953 in Prague, Czechoslovakia Education: Ing. (BS) - Agricultural College, Prague, 1978, Ph.D. - Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague, 1988, D.Sc. - Institute of Molecular Genetics, Czech Academy of Sciences, Prague, 2001, postdoctoral fellowship -- University of California at San Francisco (T. W. Kurtz, advisor), 1991-1993 Positions and affiliations: Head of Department of Genetics of Model Diseases, Institute of Physiology, Czech Academy of Sciences, Prague since 1993 Publications: 128 primary papers, cited in SCI > 3000 times Honors and awards: International Research Scholarship of the Howard Hughes Medical Institute in 1995-2000, 2001-2005, and 2006-2010.Research Summary
Dr. Michal Pravenec is interested in genetic and correlation analyses of the metabolic syndrome by studying an animal model, the spontaneously hypertensive rat (SHR) and special SHR-derived strains. He is using a genetical genomics approach in recombinant inbred (RI) strains, positional cloning of candidate genes in congenic strains and sublines and functional studies in transgenic SHR to identify responsible genetic determinants.![Research Image](images/resimg/mp_1.jpg)
Quantitative trait loci on chromosomes 1, 10, and 19 associated with systolic blood pressures (SBP) measured by radiotelemetry in recombinant inbred strains.
Publications
- T. J. Aitman, T. Gotoda, A. L. Evans, H. Imrie, K. Heath, P. Trembling, H. Truman, C. Wallace, C. Doré, J. Flint, V. Kren, T. W. Kurtz, V. Zidek, M. Pravenec, J. Scott: Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats, Nature Genet 16:197-201, 1997
- T. J. Aitman, A. M. Glazier, C. A. Wallace, L. D. Cooper, P. J. Norsworthy, K. M. Al-Majali, P. M. Trembling, C. J. Mann, C. C. Shoulders, D. Graf, E. St. Lezin, T. W. Kurtz, V. Kren, M. Pravenec, A. Ibrahimi, N. A. Abumrad, L. W. Stanton, J. Scott: Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats, Nature Genet 21:76-83, 1999
- M. Pravenec, V. Zidek, M. Simakova, V. Kren, D. Krenova, K. Horky, M. Jachymova, B. Mikova, L. Kazdova, T. J. Aitman, P. C. Churchill, N. H. Hingarh, Y. Yang, J.-M. Wang, E. M. St. Lezin, T. W. Kurtz: Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension, J Clin Invest 103:1651-1657, 1999
- M. Pravenec, V. Landa, V. Zidek, A. Musilova, V. Kren, L. Kazdova, T. J. Aitman, A. M. Glazier, N. Qi, J. Wang, E. M. St. Lezin, T. W. Kurtz: Transgenic rescue of Cd36 improves insulin resistance and dyslipidemia in spontaneously hypertensive rats, Nature Genet 27:156-158, 2001
- N. Hübner, C. A. Wallace, H. Zimdahl, E. Petretto, H. Schulz, F. Maciver, M. Müller, O. Hummel, J. Monti, V. Zidek, A. Musilova, V. Kren, H. Causton, L. Game, G. Born, S. Schmidt, A. Müller, S. Cook, T. W. Kurtz, J. Whittaker, M. Pravenec, T. J. Aitman: Integrated transcriptional profiling and linkage analysis for disease gene identification, Nature Genet 37:243-253, 2005