Michal Pravenec, Ph.D.
Contactpravenec @ biomed.cas.cz
BiographyBorn: August 10, 1953 in Prague, Czechoslovakia Education: Ing. (BS) - Agricultural College, Prague, 1978, Ph.D. - Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague, 1988, D.Sc. - Institute of Molecular Genetics, Czech Academy of Sciences, Prague, 2001, postdoctoral fellowship -- University of California at San Francisco (T. W. Kurtz, advisor), 1991-1993 Positions and affiliations: Head of Department of Genetics of Model Diseases, Institute of Physiology, Czech Academy of Sciences, Prague since 1993 Publications: 128 primary papers, cited in SCI > 3000 times Honors and awards: International Research Scholarship of the Howard Hughes Medical Institute in 1995-2000, 2001-2005, and 2006-2010.
Research SummaryDr. Michal Pravenec is interested in genetic and correlation analyses of the metabolic syndrome by studying an animal model, the spontaneously hypertensive rat (SHR) and special SHR-derived strains. He is using a genetical genomics approach in recombinant inbred (RI) strains, positional cloning of candidate genes in congenic strains and sublines and functional studies in transgenic SHR to identify responsible genetic determinants.
Quantitative trait loci on chromosomes 1, 10, and 19 associated with systolic blood pressures (SBP) measured by radiotelemetry in recombinant inbred strains.
- T. J. Aitman, T. Gotoda, A. L. Evans, H. Imrie, K. Heath, P. Trembling, H. Truman, C. Wallace, C. Doré, J. Flint, V. Kren, T. W. Kurtz, V. Zidek, M. Pravenec, J. Scott: Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats, Nature Genet 16:197-201, 1997
- T. J. Aitman, A. M. Glazier, C. A. Wallace, L. D. Cooper, P. J. Norsworthy, K. M. Al-Majali, P. M. Trembling, C. J. Mann, C. C. Shoulders, D. Graf, E. St. Lezin, T. W. Kurtz, V. Kren, M. Pravenec, A. Ibrahimi, N. A. Abumrad, L. W. Stanton, J. Scott: Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats, Nature Genet 21:76-83, 1999
- M. Pravenec, V. Zidek, M. Simakova, V. Kren, D. Krenova, K. Horky, M. Jachymova, B. Mikova, L. Kazdova, T. J. Aitman, P. C. Churchill, N. H. Hingarh, Y. Yang, J.-M. Wang, E. M. St. Lezin, T. W. Kurtz: Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension, J Clin Invest 103:1651-1657, 1999
- M. Pravenec, V. Landa, V. Zidek, A. Musilova, V. Kren, L. Kazdova, T. J. Aitman, A. M. Glazier, N. Qi, J. Wang, E. M. St. Lezin, T. W. Kurtz: Transgenic rescue of Cd36 improves insulin resistance and dyslipidemia in spontaneously hypertensive rats, Nature Genet 27:156-158, 2001
- N. Hübner, C. A. Wallace, H. Zimdahl, E. Petretto, H. Schulz, F. Maciver, M. Müller, O. Hummel, J. Monti, V. Zidek, A. Musilova, V. Kren, H. Causton, L. Game, G. Born, S. Schmidt, A. Müller, S. Cook, T. W. Kurtz, J. Whittaker, M. Pravenec, T. J. Aitman: Integrated transcriptional profiling and linkage analysis for disease gene identification, Nature Genet 37:243-253, 2005